Publications

Authorship

Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells.

Heuser C, Gotot J, Piotrowski EC, Philipp MS, Courrèges CJF, Otte MS, Guo L, Schmid-Burgk JL, Hornung V, Heine A, Knolle PA, Garbi N, Serfling E, Evaristo C, Thaiss F, Kurts C.

Cell Rep. 2017 Oct 17;21(3):578-586. doi: 10.1016/j.celrep.2017.09.082.

 

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Cossarizza A, Chang HD, Radbruch A, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O’Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J.

Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632. No abstract available.

 

Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination.

Heine A, Flores C, Gevensleben H, Diehl L, Heikenwalder M, Ringelhan M, Janssen KP, Nitsche U, Garbi N, Brossart P, Knolle PA, Kurts C, Höchst B.

Oncoimmunology. 2017 Jun 16;6(8):e1338995. doi: 10.1080/2162402X.2017.1338995. eCollection 2017.

Rescue of T-cell function during persistent pulmonary adenoviral infection by Toll-like receptor 9 activation.

Holland T, Wohlleber D, Marx S, Kreutzberg T, Vento-Asturias S, Schmitt-Mbamunyo C, Welz M, Janas M, Komander K, Eickhoff S, Brewitz A, Hasenberg M, Männ L, Gunzer M, Wilhelm C, Kastenmüller W, Knolle P, Abdullah Z, Kurts C, Garbi N.

J Allergy Clin Immunol. 2017 Aug 19. pii: S0091-6749(17)31282-4. doi: 10.1016/j.jaci.2017.06.048. [Epub ahead of print] No abstract available.

 

RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection.

Coch C, Stümpel JP, Lilien-Waldau V, Wohlleber D, Kümmerer BM, Bekeredjian-Ding I, Kochs G, Garbi N, Herberhold S, Schuberth-Wagner C, Ludwig J, Barchet W, Schlee M, Hoerauf A, Bootz F, Staeheli P, Hartmann G, Hartmann E.

Mol Ther. 2017 Sep 6;25(9):2093-2103. doi: 10.1016/j.ymthe.2017.07.003. Epub 2017 Jul 8.

Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150+ long-term repopulating murine hematopoietic stem cells.

Tornack J, Kawano Y, Garbi N, Hämmerling GJ, Melchers F, Tsuneto M.

Eur J Immunol. 2017 Sep;47(9):1477-1487. doi: 10.1002/eji.201646730. Epub 2017 Jul 26.

Location, function, and ontogeny of pulmonary macrophages during the steady state.

Garbi N, Lambrecht BN.

Pflugers Arch. 2017 Apr;469(3-4):561-572. doi: 10.1007/s00424-017-1965-3. Epub 2017 Mar 13. Review.

Distinct Expression and Function of FcεRII in Human B Cells and Monocytes.

Peng W, Grobe W, Walgenbach-Brünagel G, Flicker S, Yu C, Sylvester M, Allam JP, Oldenburg J, Garbi N, Valenta R, Novak N.

J Immunol. 2017 Apr 15;198(8):3033-3044. doi: 10.4049/jimmunol.1601028. Epub 2017 Mar 8.

CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming.

Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W.  Immunity. 2017

 

MTSS1 is epigenetically regulated in glioma cells and inhibits glioma cell motility.

Luxen D, Gielen GH, Waha A, Isselstein L, Müller T, Koch P, Hammes J, Becker A, Simon M, Wurst P, Endl E, Pietsch T, Gessi M, Waha A.

Transl Oncol. 2017 Feb;10(1):70-79. doi: 10.1016/j.tranon.2016.11.006. Epub 2016 Dec 15.

Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus.

Jansen F, Wang H, Przybilla D, Franklin BS, Dolf A, Pfeifer P, Schmitz T, Flender A, Endl E, Nickenig G, Werner N.

Cardiovasc Diabetol. 2016 Mar 22;15:49. doi: 10.1186/s12933-016-0367-8.

Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells.

Luu TT, Ganesan S, Wagner AK, Sarhan D, Meinke S, Garbi N, Hämmerling G, Alici E, Kärre K, Chambers BJ, Höglund P, Kadri N.

Sci Rep. 2016 Dec 1;6:37996. doi: 10.1038/srep37996.

CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells.

Evers BD, Engel DR, Böhner AM, Tittel AP, Krause TA, Heuser C, Garbi N, Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts C.

J Am Soc Nephrol. 2016 Nov;27(11):3368-3382. Epub 2016 Apr 1.

 

RAGE Enhances TLR Responses through Binding and Internalization of RNA.

Bertheloot D, Naumovski AL, Langhoff P, Horvath GL, Jin T, Xiao TS, Garbi N, Agrawal S, Kolbeck R, Latz E.

J Immunol. 2016 Nov 15;197(10):4118-4126. Epub 2016 Oct 19.

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis.

Schietinger A, Philip M, Krisnawan VE, Chiu EY, Delrow JJ, Basom RS, Lauer P, Brockstedt DG, Knoblaugh SE, Hämmerling GJ, Schell TD, Garbi N, Greenberg PD.

Immunity. 2016 Aug 16;45(2):389-401. doi: 10.1016/j.immuni.2016.07.011. Epub 2016 Aug 9.

Inflammasome-Dependent Induction of Adaptive NK Cell Memory.

van den Boorn JG, Jakobs C, Hagen C, Renn M, Luiten RM, Melief CJ, Tüting T, Garbi N, Hartmann G, Hornung V.

Immunity. 2016 Jun 21;44(6):1406-21. doi: 10.1016/j.immuni.2016.05.008. Epub 2016 Jun 7.

MicroRNA expression in circulating microvesicles predicts cardiovascular events in patients with coronary artery disease.

Jansen F, Yang X, Proebsting S, Hoelscher M, Przybilla D, Baumann K, Schmitz T, Dolf A, Endl E, Franklin BS, Sinning JM, Vasa-Nicotera M, Nickenig G, Werner N.

J Am Heart Assoc. 2014 Oct 27;3(6):e001249. doi: 10.1161/JAHA.114.001249.

SRC signaling is crucial in the growth of synovial sarcoma cells.

Michels S, Trautmann M, Sievers E, Kindler D, Huss S, Renner M, Friedrichs N, Kirfel J, Steiner S, Endl E, Wurst P, Heukamp L, Penzel R, Larsson O, Kawai A, Tanaka S, Sonobe H, Schirmacher P, Mechtersheimer G, Wardelmann E, Büttner R, Hartmann W.

Cancer Res. 2013 Apr 15;73(8):2518-28. doi: 10.1158/0008-5472.CAN-12-3023. Epub 2013 Apr 11.

 

Phosphatidylinositol-3′-kinase/AKT signaling is essential in synovial sarcoma.

Friedrichs N, Trautmann M, Endl E, Sievers E, Kindler D, Wurst P, Czerwitzki J, Steiner S, Renner M, Penzel R, Koch A, Larsson O, Tanaka S, Kawai A, Schirmacher P, Mechtersheimer G, Wardelmann E, Buettner R, Hartmann W.

Int J Cancer. 2011 Oct 1;129(7):1564-75. doi: 10.1002/ijc.25829. Epub 2011 Mar 4.

Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures.

Mayer G, Ahmed MS, Dolf A, Endl E, Knolle PA, Famulok M.

Nat Protoc. 2010 Dec;5(12):1993-2004. doi: 10.1038/nprot.2010.163. Epub 2010 Dec 2.

 

Laser-assisted photoablation of human pluripotent stem cells from differentiating cultures.

Terstegge S, Winter F, Rath BH, Laufenberg I, Schwarz C, Leinhaas A, Levold F, Dolf A, Haupt S, Koch P, Endl E, Brüstle O.

Stem Cell Rev. 2010 Jun;6(2):260-9. doi: 10.1007/s12015-010-9114-9.

 

Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells.

Schurich A, Böttcher JP, Burgdorf S, Penzler P, Hegenbarth S, Kern M, Dolf A, Endl E, Schultze J, Wiertz E, Stabenow D, Kurts C, Knolle P.

Hepatology. 2009 Sep;50(3):909-19. doi: 10.1002/hep.23075.

Flow cytometric purification of Colletotrichum higginsianum biotrophic hyphae from Arabidopsis leaves for stage-specific transcriptome analysis.

Takahara H, Dolf A, Endl E, O’Connell R.

Plant J. 2009 Aug;59(4):672-83. doi: 10.1111/j.1365-313X.2009.03896.x. Epub 2009 Apr 11.

Enrichment of cell-targeting and population-specific aptamers by fluorescence-activated cell sorting.

Raddatz MS, Dolf A, Endl E, Knolle P, Famulok M, Mayer G.

Angew Chem Int Ed Engl. 2008;47(28):5190-3. doi: 10.1002/anie.200800216. No abstract available.

Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro.

Klotz L, Diehl L, Dani I, Neumann H, von Oppen N, Dolf A, Endl E, Klockgether T, Engelhardt B, Knolle P.

J Neuroimmunol. 2007 Oct;190(1-2):34-43. Epub 2007 Aug 24.

Bypassing genomic imprinting allows seed development.

Nowack MK, Shirzadi R, Dissmeyer N, Dolf A, Endl E, Grini PE, Schnittger A.

Nature. 2007 May 17;447(7142):312-5. Epub 2007 Apr 29.

 

Publications supported by the FCCF and Acknowledgements

Hackstein CP, Assmus LM, Welz M, Klein S, Schwandt T, Schultze J, Förster I, Gondorf F, Beyer M, Kroy D, Kurts C, Trebicka J, Kastenmüller W, Knolle PA, Abdullah Z. Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis. Gut. 2017

Rodrigo MB, Schulz S, Krupp V, Ritter M, Wiszniewsky K, Arndts K, Tamadaho RS, Endl E, Hoerauf A, Layland LE.  Patency of Litomosoides sigmodontis infection depends on Toll-like receptor 4 whereas Toll-like receptor 2 signalling influences filarial-specific CD4(+) T-cell responses. Immunology. 2016

Schmid-Burgk JL, Chauhan D, Schmidt T, Ebert TS, Reinhardt J, Endl E, Hornung V. A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation. J Biol Chem. 2016

Böttcher, J.P., Beyer, M., Meissner, F., Abdullah, Z., Sander, J., Höchst, B., Eickhoff, S., Rieckmann, J.C., Russo, C., Bauer, T., et al. (2015). Functional classification of memory CD8+ T cells by CX3CR1 expression. Nat Commun 6, 8306.

Franken, L., Klein, M., Spasova, M., Elsukova, A., Wiedwald, U., Welz, M., Knolle, P., Farle, M., Limmer, A., and Kurts, C. (2015). Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates. Sci Rep 5, 12940.

Qu, X., Pröll, M., Neuhoff, C., Zhang, R., Cinar, M.U., Hossain, M.M., Tesfaye, D., Große-Brinkhaus, C., Salilew-Wondim, D., Tholen, E., et al. (2015). Sulforaphane Epigenetically Regulates Innate Immune Responses of Porcine Monocyte-Derived Dendritic Cells Induced with Lipopolysaccharide. PLoS One 10.

Schmid-Burgk, J.L., Schmidt, T., Gaidt, M.M., Pelka, K., Latz, E., Ebert, T.S., and Hornung, V. (2014). OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines. Genome Res. 24, 1719–1723.

Schiwon, M., Weisheit, C., Franken, L., Gutweiler, S., Dixit, A., Meyer-Schwesinger, C., Pohl, J.-M., Maurice, N.J., Thiebes, S., Lorenz, K., et al. (2014). Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium. Cell 156, 456–468.

M. Wolf, S. Lossdörfer, R. Craveiro, A. Jäger, High-mobility group box protein-1 released by human-periodontal ligament cells cells modulates macrophage migration and activity in vitro, Innate Immunity , (2013).

J. Ladewig, P. Koch, O. Brüstle, Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration, Nat Neurosci advance online publication (2013), doi:10.1038/nn.3583.

Huang, L.-R., Wohlleber, D., Reisinger, F., Jenne, C.N., Cheng, R.-L., Abdullah, Z., Schildberg, F.A., Odenthal, M., Dienes, H.-P., van Rooijen, N., et al. (2013). Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. Nat. Immunol.

Böttcher, J.P., Schanz, O., Wohlleber, D., Abdullah, Z., Debey-Pascher, S., Staratschek-Jox, A., Höchst, B., Hegenbarth, S., Grell, J., Limmer, A., et al. (2013). Liver-Primed Memory T Cells Generated under Noninflammatory Conditions Provide Anti-infectious Immunity. Cell Reports 3, 779–795.

Abdullah, Z., Schlee, M., Roth, S., Mraheil, M.A., Barchet, W., Böttcher, J., Hain, T., Geiger, S., Hayakawa, Y., Fritz, J.H., et al. (2012a). RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids. EMBO J. 31, 4153–4164.

Abdullah, Z., Geiger, S., Nino-Castro, A., Böttcher, J.P., Muraliv, E., Gaidt, M., Schildberg, F.A., Riethausen, K., Flossdorf, J., Krebs, W., et al. (2012b). Lack of PPARγ in Myeloid Cells Confers Resistance to Listeria monocytogenes Infection. PLoS One 7.

Bauernfeind, F., Rieger, A., Schildberg, F.A., Knolle, P.A., Schmid-Burgk, J.L., and Hornung, V. (2012). NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223. J Immunol 189, 4175–4181.

Gotot, J., Gottschalk, C., Leopold, S., Knolle, P.A., Yagita, H., Kurts, C., and Ludwig-Portugall, I. (2012). Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo. Proc. Natl. Acad. Sci. U.S.A. 109, 10468–10473.

Höchst, B., Schildberg, F.A., Böttcher, J., Metzger, C., Huss, S., Türler, A., Overhaus, M., Knoblich, A., Schneider, B., Pantelis, D., et al. (2012). Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance toward circulating carcinoembryonic antigen in mice. Hepatology 56, 1924–1933.

Hucke, S., Floßdorf, J., Grützke, B., Dunay, I.R., Frenzel, K., Jungverdorben, J., Linnartz, B., Mack, M., Peitz, M., Brüstle, O., et al. (2012). Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor γ. Brain.

Landsberg, J., Kohlmeyer, J., Renn, M., Bald, T., Rogava, M., Cron, M., Fatho, M., Lennerz, V., Wölfel, T., Hölzel, M., et al. (2012). Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation. Nature 490, 412–416.

Schwandt, T., Schumak, B., Gielen, G.H., Jüngerkes, F., Schmidbauer, P., Klocke, K., Staratschek-Jox, A., van Rooijen, N., Kraal, G., Ludwig-Portugall, I., et al. (2012). Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis. EMBO J. 31, 201–213.

Wohlleber, D., Kashkar, H., Gaertner, K., Frings, M.K., Odenthal, M., Hegenbarth, S., Boerner, C., Arnold, B., Haemmerling, G., Nieswandt, B., et al. (2012). TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation. Cell Reports 2, 478–487.

Hochheiser, K., Engel, D.R., Hammerich, L., Heymann, F., Knolle, P.A., Panzer, U., and Kurts, C. (2011). Kidney Dendritic Cells Become Pathogenic during Crescentic Glomerulonephritis with Proteinuria. Journal of the American Society of Nephrology 22, 306 –316.

Engel, D.R., Koscielny, A., Wehner, S., Maurer, J., Schiwon, M., Franken, L., Schumak, B., Limmer, A., Sparwasser, T., Hirner, A., et al. (2010). T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract. Nat. Med. 16, 1407–1413.

Glas, M., Rath, B.H., Simon, M., Reinartz, R., Schramme, A., Trageser, D., Eisenreich, R., Leinhaas, A., Keller, M., Schildhaus, H.-U., et al. (2010). Residual tumor cells are unique cellular targets in glioblastoma. Ann Neurol. n/a–n/a.

Kern, M., Popov, A., Scholz, K., Schumak, B., Djandji, D., Limmer, A., Eggle, D., Sacher, T., Zawatzky, R., Holtappels, R., et al. (2010). Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity. Gastroenterology 138, 336–346.

Schurich, A., Berg, M., Stabenow, D., Bottcher, J., Kern, M., Schild, H.-J., Kurts, C., Schuette, V., Burgdorf, S., Diehl, L., et al. (2010). Dynamic Regulation of CD8 T Cell Tolerance Induction by Liver Sinusoidal Endothelial Cells. J Immunol 184, 4107–4114.

Semmling, V., Lukacs-Kornek, V., Thaiss, C.A., Quast, T., Hochheiser, K., Panzer, U., Rossjohn, J., Perlmutter, P., Cao, J., Godfrey, D.I., et al. (2010). Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nat Immunol 11, 313–320.

Alex, A., Spitznas, M., Tittel, A., Kurts, C., and Eter, N. (2010). Inhibitory Effect of Epigallocatechin Gallate (EGCG), Resveratrol, and Curcumin on Proliferation of Human Retinal Pigment Epithelial Cells In Vitro. Current Eye Research 35, 1021-1033.

Burgdorf, S., Schuette, V., Semmling, V., Hochheiser, K., Lukacs-Kornek, V., Knolle, P. A., and Kurts, C. (2010a). Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments. Proc. Natl. Acad. Sci. U.S.A 107, E48-49; author reply E50-51.

Burgdorf, S., Schuette, V., Semmling, V., Hochheiser, K., Lukacs-Kornek, V., Knolle, P. A., and Kurts, C. (2010b). Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments. Proceedings of the National Academy of Sciences 107, E48-E49.

Glas, M., Rath, B. H., Simon, M., Reinartz, R., Schramme, A., Trageser, D., Eisenreich, R., Leinhaas, A., Keller, M., Schildhaus, H., et al. (2010). Residual tumor cells are unique cellular targets in glioblastoma. Ann Neurol., n/a-n/a.

Kern, M., Popov, A., Scholz, K., Schumak, B., Djandji, D., Limmer, A., Eggle, D., Sacher, T., Zawatzky, R., Holtappels, R., et al. (2010). Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity. Gastroenterology 138, 336-346.

Schurich, A., Berg, M., Stabenow, D., Bottcher, J., Kern, M., Schild, H., Kurts, C., Schuette, V., Burgdorf, S., Diehl, L., et al. (2010). Dynamic Regulation of CD8 T Cell Tolerance Induction by Liver Sinusoidal Endothelial Cells. J Immunol 184, 4107-4114.

Semmling, V., Lukacs-Kornek, V., Thaiss, C. A., Quast, T., Hochheiser, K., Panzer, U., Rossjohn, J., Perlmutter, P., Cao, J., Godfrey, D. I., et al. (2010). Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nat Immunol 11, 313-320.

Klotz, L., Burgdorf, S., et al. (2009). The nuclear receptor PPAR{gamma} selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J. Exp. Med. 206, 2079-2089.

Klotz, L., Hucke, S., et al. (2009). Increased Antigen Cross-Presentation but Impaired Cross-Priming after Activation of Peroxisome Proliferator-Activated Receptor {gamma} Is Mediated by Up-Regulation of B7H1. J Immunol 183, 129-136.

Terstegge, S., Rath, B. H., Laufenberg, I., Limbach, N., Buchstaller, A., Schütze, K., and Brüstle, O. (2009). Laser-assisted selection and passaging of human pluripotent stem cell colonies. Journal of Biotechnology 143, 224-230.

Heymann, F., Meyer-Schwesinger, C., Hamilton-Williams, E. E., Hammerich, L., Panzer, U., Kaden, S., Quaggin, S. E., Floege, J., Gröne, H., and Kurts, C. (2009). Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J. Clin. Invest 119, 1286-1297.

Janke, M., Poth, J., Wimmenauer, V., Giese, T., Coch, C., Barchet, W., Schlee, M., and Hartmann, G. (2009). Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8. J Allergy Clin Immunol. .

Ludwig-Portugall, I., Hamilton-Williams, E. E., Gotot, J., and Kurts, C. (2009). CD25+ T(reg) specifically suppress auto-Ab generation against pancreatic tissue autoantigens. Eur. J. Immunol 39, 225-233.

Lukacs-Kornek, V., Burgdorf, S., Diehl, L., Specht, S., Kornek, M., and Kurts, C. (2008). The kidney-renal lymph node-system contributes to cross-tolerance against innocuous circulating antigen. J Immunol 180, 706-15.

Lukacs-Kornek, V., Engel, D., Tacke, F., and Kurts, C. (2008). The role of chemokines and their receptors in dendritic cell biology. Front Biosci 13, 2238-52.

von Oppen, N., Schurich, A., Hegenbarth, S., Stabenow, D., Tolba, R., Weiskirchen, R., Geerts, A., Kolanus, W., Knolle, P., and Diehl, L. (2008). Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization. Hepatology 49, 1664-1672.

Scholz, J., Lukacs-Kornek, V., Engel, D. R., Specht, S., Kiss, E., Eitner, F., Floege, J., Groene, H., and Kurts, C. (2008). Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis. J Am Soc Nephrol 19, 527-37.

Burgdorf, S., Schölz, C., Kautz, A., Tampé, R., and Kurts, C. (2008). Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nat Immunol 9, 558-66.

Diehl, L., Schurich, A., Grochtmann, R., Hegenbarth, S., Chen, L., and Knolle, P. A. (2008). Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance. Hepatology 47, 296-305.

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