Publications

Authorship

Peng W, Grobe W, Walgenbach-Brünagel G, Flicker S, Yu C, Sylvester M, Allam JP, Oldenburg J, Garbi N, Valenta R, Novak N. Distinct Expression and Function of FcεRII in Human B Cells and Monocytes. J Immunol. 2017

Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W. CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming. Immunity. 2017

Luxen D, Gielen GH, Waha A, Isselstein L, Müller T, Koch P, Hammes J, Becker A, Simon M, Wurst P, Endl E, Pietsch T, Gessi M, Waha A. MTSS1 is epigenetically regulated in glioma cells and inhibits glioma cell motility. Transl Oncol. 2017

Jansen F, Wang H, Przybilla D, Franklin BS, Dolf A, Pfeifer P, Schmitz T, Flender A, Endl E, Nickenig G, Werner N.   Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus. Cardiovasc Diabetol. 2016 

Luu TT, Ganesan S, Wagner AK, Sarhan D, Meinke S, Garbi N, Hämmerling G, Alici E, Kärre K, Chambers BJ, Höglund P, Kadri N. Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells. Sci Rep. 2016

van den Boorn JG, Jakobs C, Hagen C, Renn M, Luiten RM, Melief CJ, Tüting T, Garbi N, Hartmann G, Hornung V. Inflammasome-Dependent Induction of Adaptive NK Cell Memory. Immunity. 2016

Evers BD, Engel DR, Böhner AM, Tittel AP, Krause TA, Heuser C, Garbi N, Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts C. CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells.   J Am Soc Nephrol. 2016

Jansen, F., Yang, X., Proebsting, S., Hoelscher, M., Przybilla, D., Baumann, K., Schmitz, T., Dolf, A., Endl, E., Franklin, B.S., et al. (2014). MicroRNA expression in circulating microvesicles predicts cardiovascular events in patients with coronary artery disease. J Am Heart Assoc 3, e00124

Friedrichs N, Trautmann M, Endl E, Sievers E, Kindler D, Wurst P, Czerwitzki J, Steiner S, Renner M, Penzel R, Koch A, Larsson O, Tanaka S, Kawai A, Schirmacher P, Mechtersheimer G, Wardelmann E, Buettner R, Hartmann W. Phosphatidylinositol-3′-kinase/AKT signaling is essential in synovial sarcoma. Int J Cancer. 2011

Mayer, G., Ahmed, M. L., Dolf, A., Endl, E., Knolle, P. A., and Famulok, M. (2010). Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures. Nat. Protocols 5, 1993-2004.

Küchler, J., Hartmann, W., Waha, A., Koch, A., Endl, E., Wurst, P., Kindler, D., Mikeska, T., Waha, A., Goodyer, C. G., u. a. (2010). p75(NTR) induces apoptosis in medulloblastoma cells. Int J Cancer. Available at: http://www.ncbi.nlm.nih.gov/pubmed/20549701

Terstegge, S., Winter, F., Rath, B. H., Laufenberg, I., Schwarz, C., Leinhaas, A., Levold, F., Dolf, A., Haupt, S., Koch, P., et al. (2010). Laser-Assisted Photoablation of Human Pluripotent Stem Cells from Differentiating Cultures. Stem Cell Rev. Available at: http://www.ncbi.nlm.nih.gov/pubmed/20186504 [Accessed March 31, 2010].

Schurich, A., Böttcher, J. P., Burgdorf, S., Penzler, P., Hegenbarth, S., Kern, M., Dolf, A., Endl, E., Schultze, J., Wiertz, E., u. a. (2009). Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells. Hepatology 50, 909-919.

Takahara H, Dolf A, Endl E, O’Connell R. Flow cytometric purification of Colletotrichum higginsianum biotrophic hyphae from Arabidopsis leaves for stage-specific transcriptome analysis. Plant J. 2009 Aug ;59(4):672-683.

Hartmann W, Küchler J, Koch A, Friedrichs N, Waha A, Endl E, Czerwitzki J, Metzger D, Steiner S, Wurst P, Leuschner I, von Schweinitz D, Buettner R, Pietsch T. Activation of phosphatidylinositol-3′-kinase/AKT signaling is essential in hepatoblastoma survival. Clin. Cancer Res. 2009 Juli 15;15(14):4538-4545.

Friedrichs N, Küchler J, Endl E, Koch A, Czerwitzki J, Wurst P, Metzger D, Schulte JH, Holst MI, Heukamp LC, Larsson O, Tanaka S, Kawai A, Wardelmann E, Buettner R, Pietsch T, Hartmann W. Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma. J Pathol. 2008 Dez ;216(4):428-39.

Raddatz ML, Dolf A, Endl E, Knolle P, Famulok M, Mayer G. Enrichment of cell-targeting and population-specific aptamers by fluorescence-activated cell sorting. Angew Chem Int Ed Engl. 2008 ;47(28):5190-3.

Klotz L, Diehl L, Dani I, Neumann H, von Oppen N, Dolf A, Endl E, Klockgether T, Engelhardt B, Knolle P. Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro. J Neuroimmunol. 2007 Okt ;190(1-2):34-43.

Nowack MK, Shirzadi R, Dissmeyer N, Dolf A, Endl E, Grini PE, Schnittger A. Bypassing genomic imprinting allows seed development. Nature. 2007 Mai 17;447(7142):312-5.

Publications supported by the FCCF and Acknowledgements

Hackstein CP, Assmus LM, Welz M, Klein S, Schwandt T, Schultze J, Förster I, Gondorf F, Beyer M, Kroy D, Kurts C, Trebicka J, Kastenmüller W, Knolle PA, Abdullah Z. Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis. Gut. 2017

Rodrigo MB, Schulz S, Krupp V, Ritter M, Wiszniewsky K, Arndts K, Tamadaho RS, Endl E, Hoerauf A, Layland LE.  Patency of Litomosoides sigmodontis infection depends on Toll-like receptor 4 whereas Toll-like receptor 2 signalling influences filarial-specific CD4(+) T-cell responses. Immunology. 2016

Schmid-Burgk JL, Chauhan D, Schmidt T, Ebert TS, Reinhardt J, Endl E, Hornung V. A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation. J Biol Chem. 2016

Böttcher, J.P., Beyer, M., Meissner, F., Abdullah, Z., Sander, J., Höchst, B., Eickhoff, S., Rieckmann, J.C., Russo, C., Bauer, T., et al. (2015). Functional classification of memory CD8+ T cells by CX3CR1 expression. Nat Commun 6, 8306.

Franken, L., Klein, M., Spasova, M., Elsukova, A., Wiedwald, U., Welz, M., Knolle, P., Farle, M., Limmer, A., and Kurts, C. (2015). Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates. Sci Rep 5, 12940.

Qu, X., Pröll, M., Neuhoff, C., Zhang, R., Cinar, M.U., Hossain, M.M., Tesfaye, D., Große-Brinkhaus, C., Salilew-Wondim, D., Tholen, E., et al. (2015). Sulforaphane Epigenetically Regulates Innate Immune Responses of Porcine Monocyte-Derived Dendritic Cells Induced with Lipopolysaccharide. PLoS One 10.

Schmid-Burgk, J.L., Schmidt, T., Gaidt, M.M., Pelka, K., Latz, E., Ebert, T.S., and Hornung, V. (2014). OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines. Genome Res. 24, 1719–1723.

Schiwon, M., Weisheit, C., Franken, L., Gutweiler, S., Dixit, A., Meyer-Schwesinger, C., Pohl, J.-M., Maurice, N.J., Thiebes, S., Lorenz, K., et al. (2014). Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium. Cell 156, 456–468.

M. Wolf, S. Lossdörfer, R. Craveiro, A. Jäger, High-mobility group box protein-1 released by human-periodontal ligament cells cells modulates macrophage migration and activity in vitro, Innate Immunity , (2013).

J. Ladewig, P. Koch, O. Brüstle, Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration, Nat Neurosci advance online publication (2013), doi:10.1038/nn.3583.

Huang, L.-R., Wohlleber, D., Reisinger, F., Jenne, C.N., Cheng, R.-L., Abdullah, Z., Schildberg, F.A., Odenthal, M., Dienes, H.-P., van Rooijen, N., et al. (2013). Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. Nat. Immunol.

Böttcher, J.P., Schanz, O., Wohlleber, D., Abdullah, Z., Debey-Pascher, S., Staratschek-Jox, A., Höchst, B., Hegenbarth, S., Grell, J., Limmer, A., et al. (2013). Liver-Primed Memory T Cells Generated under Noninflammatory Conditions Provide Anti-infectious Immunity. Cell Reports 3, 779–795.

Abdullah, Z., Schlee, M., Roth, S., Mraheil, M.A., Barchet, W., Böttcher, J., Hain, T., Geiger, S., Hayakawa, Y., Fritz, J.H., et al. (2012a). RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids. EMBO J. 31, 4153–4164.

Abdullah, Z., Geiger, S., Nino-Castro, A., Böttcher, J.P., Muraliv, E., Gaidt, M., Schildberg, F.A., Riethausen, K., Flossdorf, J., Krebs, W., et al. (2012b). Lack of PPARγ in Myeloid Cells Confers Resistance to Listeria monocytogenes Infection. PLoS One 7.

Bauernfeind, F., Rieger, A., Schildberg, F.A., Knolle, P.A., Schmid-Burgk, J.L., and Hornung, V. (2012). NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223. J Immunol 189, 4175–4181.

Gotot, J., Gottschalk, C., Leopold, S., Knolle, P.A., Yagita, H., Kurts, C., and Ludwig-Portugall, I. (2012). Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo. Proc. Natl. Acad. Sci. U.S.A. 109, 10468–10473.

Höchst, B., Schildberg, F.A., Böttcher, J., Metzger, C., Huss, S., Türler, A., Overhaus, M., Knoblich, A., Schneider, B., Pantelis, D., et al. (2012). Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance toward circulating carcinoembryonic antigen in mice. Hepatology 56, 1924–1933.

Hucke, S., Floßdorf, J., Grützke, B., Dunay, I.R., Frenzel, K., Jungverdorben, J., Linnartz, B., Mack, M., Peitz, M., Brüstle, O., et al. (2012). Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor γ. Brain.

Landsberg, J., Kohlmeyer, J., Renn, M., Bald, T., Rogava, M., Cron, M., Fatho, M., Lennerz, V., Wölfel, T., Hölzel, M., et al. (2012). Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation. Nature 490, 412–416.

Schwandt, T., Schumak, B., Gielen, G.H., Jüngerkes, F., Schmidbauer, P., Klocke, K., Staratschek-Jox, A., van Rooijen, N., Kraal, G., Ludwig-Portugall, I., et al. (2012). Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis. EMBO J. 31, 201–213.

Wohlleber, D., Kashkar, H., Gaertner, K., Frings, M.K., Odenthal, M., Hegenbarth, S., Boerner, C., Arnold, B., Haemmerling, G., Nieswandt, B., et al. (2012). TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation. Cell Reports 2, 478–487.

Hochheiser, K., Engel, D.R., Hammerich, L., Heymann, F., Knolle, P.A., Panzer, U., and Kurts, C. (2011). Kidney Dendritic Cells Become Pathogenic during Crescentic Glomerulonephritis with Proteinuria. Journal of the American Society of Nephrology 22, 306 –316.

Engel, D.R., Koscielny, A., Wehner, S., Maurer, J., Schiwon, M., Franken, L., Schumak, B., Limmer, A., Sparwasser, T., Hirner, A., et al. (2010). T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract. Nat. Med. 16, 1407–1413.

Glas, M., Rath, B.H., Simon, M., Reinartz, R., Schramme, A., Trageser, D., Eisenreich, R., Leinhaas, A., Keller, M., Schildhaus, H.-U., et al. (2010). Residual tumor cells are unique cellular targets in glioblastoma. Ann Neurol. n/a–n/a.

Kern, M., Popov, A., Scholz, K., Schumak, B., Djandji, D., Limmer, A., Eggle, D., Sacher, T., Zawatzky, R., Holtappels, R., et al. (2010). Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity. Gastroenterology 138, 336–346.

Schurich, A., Berg, M., Stabenow, D., Bottcher, J., Kern, M., Schild, H.-J., Kurts, C., Schuette, V., Burgdorf, S., Diehl, L., et al. (2010). Dynamic Regulation of CD8 T Cell Tolerance Induction by Liver Sinusoidal Endothelial Cells. J Immunol 184, 4107–4114.

Semmling, V., Lukacs-Kornek, V., Thaiss, C.A., Quast, T., Hochheiser, K., Panzer, U., Rossjohn, J., Perlmutter, P., Cao, J., Godfrey, D.I., et al. (2010). Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nat Immunol 11, 313–320.

Alex, A., Spitznas, M., Tittel, A., Kurts, C., and Eter, N. (2010). Inhibitory Effect of Epigallocatechin Gallate (EGCG), Resveratrol, and Curcumin on Proliferation of Human Retinal Pigment Epithelial Cells In Vitro. Current Eye Research 35, 1021-1033.

Burgdorf, S., Schuette, V., Semmling, V., Hochheiser, K., Lukacs-Kornek, V., Knolle, P. A., and Kurts, C. (2010a). Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments. Proc. Natl. Acad. Sci. U.S.A 107, E48-49; author reply E50-51.

Burgdorf, S., Schuette, V., Semmling, V., Hochheiser, K., Lukacs-Kornek, V., Knolle, P. A., and Kurts, C. (2010b). Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments. Proceedings of the National Academy of Sciences 107, E48-E49.

Glas, M., Rath, B. H., Simon, M., Reinartz, R., Schramme, A., Trageser, D., Eisenreich, R., Leinhaas, A., Keller, M., Schildhaus, H., et al. (2010). Residual tumor cells are unique cellular targets in glioblastoma. Ann Neurol., n/a-n/a.

Kern, M., Popov, A., Scholz, K., Schumak, B., Djandji, D., Limmer, A., Eggle, D., Sacher, T., Zawatzky, R., Holtappels, R., et al. (2010). Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity. Gastroenterology 138, 336-346.

Schurich, A., Berg, M., Stabenow, D., Bottcher, J., Kern, M., Schild, H., Kurts, C., Schuette, V., Burgdorf, S., Diehl, L., et al. (2010). Dynamic Regulation of CD8 T Cell Tolerance Induction by Liver Sinusoidal Endothelial Cells. J Immunol 184, 4107-4114.

Semmling, V., Lukacs-Kornek, V., Thaiss, C. A., Quast, T., Hochheiser, K., Panzer, U., Rossjohn, J., Perlmutter, P., Cao, J., Godfrey, D. I., et al. (2010). Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nat Immunol 11, 313-320.

Klotz, L., Burgdorf, S., et al. (2009). The nuclear receptor PPAR{gamma} selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J. Exp. Med. 206, 2079-2089.

Klotz, L., Hucke, S., et al. (2009). Increased Antigen Cross-Presentation but Impaired Cross-Priming after Activation of Peroxisome Proliferator-Activated Receptor {gamma} Is Mediated by Up-Regulation of B7H1. J Immunol 183, 129-136.

Terstegge, S., Rath, B. H., Laufenberg, I., Limbach, N., Buchstaller, A., Schütze, K., and Brüstle, O. (2009). Laser-assisted selection and passaging of human pluripotent stem cell colonies. Journal of Biotechnology 143, 224-230.

Heymann, F., Meyer-Schwesinger, C., Hamilton-Williams, E. E., Hammerich, L., Panzer, U., Kaden, S., Quaggin, S. E., Floege, J., Gröne, H., and Kurts, C. (2009). Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J. Clin. Invest 119, 1286-1297.

Janke, M., Poth, J., Wimmenauer, V., Giese, T., Coch, C., Barchet, W., Schlee, M., and Hartmann, G. (2009). Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8. J Allergy Clin Immunol. .

Ludwig-Portugall, I., Hamilton-Williams, E. E., Gotot, J., and Kurts, C. (2009). CD25+ T(reg) specifically suppress auto-Ab generation against pancreatic tissue autoantigens. Eur. J. Immunol 39, 225-233.

Lukacs-Kornek, V., Burgdorf, S., Diehl, L., Specht, S., Kornek, M., and Kurts, C. (2008). The kidney-renal lymph node-system contributes to cross-tolerance against innocuous circulating antigen. J Immunol 180, 706-15.

Lukacs-Kornek, V., Engel, D., Tacke, F., and Kurts, C. (2008). The role of chemokines and their receptors in dendritic cell biology. Front Biosci 13, 2238-52.

von Oppen, N., Schurich, A., Hegenbarth, S., Stabenow, D., Tolba, R., Weiskirchen, R., Geerts, A., Kolanus, W., Knolle, P., and Diehl, L. (2008). Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization. Hepatology 49, 1664-1672.

Scholz, J., Lukacs-Kornek, V., Engel, D. R., Specht, S., Kiss, E., Eitner, F., Floege, J., Groene, H., and Kurts, C. (2008). Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis. J Am Soc Nephrol 19, 527-37.

Burgdorf, S., Schölz, C., Kautz, A., Tampé, R., and Kurts, C. (2008). Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nat Immunol 9, 558-66.

Diehl, L., Schurich, A., Grochtmann, R., Hegenbarth, S., Chen, L., and Knolle, P. A. (2008). Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance. Hepatology 47, 296-305.

Engel, D. R., Maurer, J., Tittel, A. P., Weisheit, C., Cavlar, T., Schumak, B., Limmer, A., van Rooijen, N., Trautwein, C., Tacke, F., et al. (2008). CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection. J. Immunol 181, 5579-5586.

Eter, N., Engel, D. R., Meyer, L., Helb, H., Roth, F., Maurer, J., Holz, F. G., and Kurts, C. (2008). In Vivo Visualization of Dendritic Cells, Macrophages, and Microglial Cells Responding to Laser-Induced Damage in the Fundus of the Eye. Invest. Ophthalmol. Vis. Sci. 49, 3649-3658.

Friedrichs, N., Küchler, J., Endl, E., Koch, A., Czerwitzki, J., Wurst, P., Metzger, D., Schulte, J., Holst, M., Heukamp, L., et al. (2008). Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma. J Pathol. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18855347 [Accessed October 22, 2008].

Burgdorf, S., Kautz, A., Böhnert, V., Knolle, P. A., and Kurts, C. (2007). Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science 316, 612-6.