Zebrafish without stripes

Dowling-Degos disease is a hereditary pigmentation disorder that generally progresses harmlessly. However, some of those affected also develop severe skin inflammation. An international team of researchers under the leadership of the University of Bonn has now found a cause for this link. Their knowledge comes thanks to an animal that is known among aquarium owners for its characteristic pigmentation: the zebrafish. The results have now been published in the Journal of Clinical Investigation.

Publication: Damian Ralser et al.: Mutations in gamma-secretase subunit–encoding PSENEN underlie Dowling-Degos disease associated with acne inversa; Journal of Clinical Investigation; DOI: 10.1172/JCI90667

Contact:

Prof. Regina Betz
Institute of Human Genetics
University of Bonn
Tel. +49 (0)228/28751023
E-mail: regina.betz@uni-bonn.de

Prof. Benjamin Odermatt
Anatomical Institute

Zebrafish Core Facility
University of Bonn
Tel. +49 (0)228/739021
E-mail: b.odermatt@uni-bonn.de